Hello good people of the world! Continuing the series on oral solid dosage forms, today we’re going to talk about material handling. Oral solid dose manufacturing is typically a batch process, which means materials need to be transferred from step-to-step. Sometimes there is direct conveyance between steps, but often transfer is performed via Intermediate Bulk Container (IBC).
In terms of design, IBCs should be able to handle the worst-case (lowest) density material in the process. IBCs should be cleanable, especially if a single container will support many product manufacturing processes. IBCs should be designed in such a way that they drain easily. Charging/discharging must be considered.
IBCs may be transported on wheels, or by a pallet truck.
Discharging may be facilitated by applying vibrations to the IBC, either internally or externally.
For direct conveyance, gravity, pneumatic conveyance, and mechanical conveyors are options.
What considerations around material handling do you have in your OSD lines? Comment below!
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